A CYP3A4 Phenotype–Based Dosing Algorithm for Individualized Treatment of Irinotecan
نویسندگان
چکیده
منابع مشابه
Individualizing dosing of irinotecan.
Individualized drug dosing is a longstanding goal of clinical pharmacologists. Given the narrow therapeutic index of most anticancer agents, it is plausible that this approach would be of particular value in oncology. Irinotecan is an interesting agent for individualized dosing, given its complex metabolism and increasing knowledge of its pharmacokinetics predictors.
متن کاملAlternative dosing schedules for irinotecan.
Most of the clinical experience with irinotecan (CPT-11 [Camptosar]) has been with either a weekly or an every-3-week schedule. Recent phase I trials have explored new routes and schedules of administration. One approach attempts to maximize dose frequency and intensity by giving irinotecan every 2 weeks. A phase I trial of this approach is now complete and has led to a phase II trial in patien...
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چکیده ندارد.
15 صفحه اولPegylated interferon fractal pharmacokinetics: individualized dosing for hepatitis C virus
24 Background : Despite recent advances in hepatitis C virus (HCV) therapeutics, the combination 25 of pegylated interferon (PEGIFN) and ribavirin (RBV) remains the cornerstone of treatment. 26 Optimization and individualization of PEGIFN dosing could improve outcomes. 27 Methods: Week one PEGIFN serum concentrations in 42 HCV genotype 1 infected patients 28 treated with conventional PEGIFN/RBV...
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There is no personalized anticancer treatment without individualized dosing. Clearly, BSA-based chemotherapy dosing does not improve the substantial pharmacokinetic variability of individual drugs. Similarly, the new oral kinase inhibitors and endocrine compounds exhibit a marked pharmacokinetic variability due to variable absorption, hepatic metabolism and potential drug-drug and food-drug int...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2010
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-09-1526